Cell thiab Gene Therapy (CGT) Access Model-
Medi-Cal Cov Lus Nug Nug Txog Tus Tswv Cuab (FAQs)
Hloov kho Lub Yim Hli 1, 2025
Cov FAQs hauv qab no muab kev qhia ntxiv thiab kev qhia meej rau cov tswv cuab Medi-Cal txog CGT Access Model. Raws li Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv (DHCS) tau txais cov lus nug ntxiv, FAQ no yuav raug hloov kho. Yog xav paub ntxiv txog CGT Access Model, thov xa mus rau General FAQs.
General
What might my CGT treatment journey look like under Medi-Cal’s CGT Access Model?
Ib tug tswv cuab txoj kev taug kev tau txais kev kho mob CGT yuav suav nrog cov hauv qab no:
- Kev sab laj nrog hematologists thiab lwm tus kws kho mob tshwj xeeb
- Kev ntsuam xyuas tag nrho ntawm qhov chaw kho mob suav nrog kev xav tau ntawm lub cev, kev xav tau ntawm tus cwj pwm kev noj qab haus huv, thiab kev xav tau kev txhawb nqa kev sib raug zoo
- Kev sib koom tes ntawm kev saib xyuas thiab kev pab txhawb nqa rau cov tswv cuab thiab tsev neeg taug txoj kev kho mob
- Kev tswj kab mob hauv kev npaj rau CGT
- Fertility preservation Services
- Gene therapy infusion thiab kev pabcuam rov qab
- Kev kho mob tom qab kev kho mob
How do I know which CGT SCD medication I will receive through Medi-Cal’s CGT Access Model?
Medi-Cal’s CGT Access Model will cover the two federal Food and Drug Administration (FDA)-approved CGT medications for treatment of sickle cell disease (SCD). This includes, CASGEVY™, which is made by Vertex Pharmaceuticals, Inc., and LYFGENIA™, which is made by bluebird bio, Inc. Your doctor will determine which CGT SCD medication is most appropriate for your individual circumstances and submit the necessary request on your behalf so you can participate in the CGT Access Model and receive the CGT SCD medication.
Can CGT medications for SCD affect my fertility (ability to have children)?
Yes, chemotherapy used in stem cell transplants during CGT treatments may impact your fertility (ability to have children). However, because of this fact, fertility preservation services are covered and available to members under Medi-Cal’s CGT Access Model. You are encouraged to discuss fertility preservation options with your doctor once approved for but before starting CGT treatment. Please see the Covered CGT Access Model Services, Including Fertility Preservation Services section of this FAQ for more information.
Kev tsim nyog
Am I eligible to participate in Medi-Cal’s CGT Access Model and receive CGT SCD medications?
Medi-Cal cov tswv cuab yuav tsum ua tau raws li txhua yam hauv qab no:
- Muaj cov ntaub ntawv kho mob ntawm SCD;
- Nkag mus rau npe rau hauv Medi-Cal puv npo thaum lub sijhawm tau txais cov tshuaj CGT (ceeb toom: ob qho tib si Medi-Cal tswj hwm kev saib xyuas thiab tus nqi-rau-kev pabcuam (FFS) cov tswvcuab yuav tsim nyog tau txais kev kho CGT);
- Muaj Medi-Cal ua lawv tus thawj them nyiaj;
- Tau txais ib qho ntawm ob qho tshuaj CGT los ntawm tus kws kho mob koom nrog; thiab
- Ua kom txaus siab rau tag nrho cov CGT Access Model raws li txoj cai tau tshaj tawm Medi-Cal raws li tau teev tseg hauv Medi-Cal Tus Muab Kev Pab Cuam thiab siv tau Txhua Daim Ntawv Npaj.
Nkag mus rau CGT Access Model Services
How do I access CGT SCD medications under Medi-Cal’s GCT Access Model?
If you have Medi-Cal FFS, you should consult with your doctor to determine eligibility and learn more as well as for information on accessing CGT SCD medications. Medi-Cal FFS providers can assist members with accessing one of the two CGT SCD medications.
Medi-Cal managed care members should contact their doctor or Medi-Cal managed care plan (MCP) to determine eligibility and learn more about CGT services. Medi-Cal MCPs are responsible for care coordination and assisting members with accessing one of the two CGT sickle cell disease medications. For more information on Medi-Cal MCP care coordination and other requirements, please review the applicable All Plan Letter on DHCS’ website. Each Medi-Cal MCP includes a point of contact, which can be found in the Medi-Cal Managed Care Health Plan Directory.
If approved for participation in Medi-Cal’s CGT Access Model to receive LYFGENIA, where will that happen?
LYFGENIA treatments are only available and administered at Qualified Treatment Centers (QTCs) centers that have the appropriate experience and training to do so. There are currently eight (8) QTCs that offer LYFGENIA in California, which are bulleted below. You may search for QTCs closest to you on this website: LYFGENIA™ (lovotibeglogene autotemcel) Qualified Treatment Center Locator. Your LYFGENIA patient navigator (available with mybluebirdbio enrollment) may also assist you with identifying a QTC closet to you.
Northern California:
UCSF Benioff Children’s Hospital
Oakland 747 52nd Street, Oakland, CA 94608
510-428-3000
UCSF Benioff Children’s Hospital San Francisco
1975 4th Street, San Francisco, CA 94158
415-476-2188
Lucile Packard Children’s Hospital at Stanford
725 Welch Road, Palo Alto, CA 94304
650-725-3158
Southern California:
UCLA
757 Westwood Plaza, Los Angeles, CA 90095
310-260-6909
310-825-6708
Children’s Hospital Los Angeles
4650 Sunset Blvd., Los Angeles, CA 90027
323-361-4624
City of Hope National Medical Center
1500 E Duarte Road, Duarte CA, 91010
1-800-826-4673
Loma Linda University Children’s Hospital
11234 Anderson Street, Loma Linda, CA 92354
909-558-4000
Loma Linda University Medical Center
11234 Anderson Street, Loma Linda, CA 92354
909-558-4000
If approved for participation in Medi-Cal’s CGT Access Model to receive CASGEVY, where will that happen?
CASGEVY treatments are only available and administered at Authorized Treatment Centers (ATCs) that have the appropriate experience and training to do so. There are 6 ATCs that offer CASGEVY in California. You may search for ATCs closest to you on this website: Authorized Treatment Center Locator | CASGEVY® (exagamglogene autotemcel).
Northern California:
UCSF Benioff Children’s Hospital San Francisco
1975 4th Street
San Francisco, 94158
Benioff Children’s Hospital Oakland
747 52nd St.
Oakland, 94609
(510) 428-3885 ext. 5183
amy.solari@ucsf.edu
Southern California:
City of Hope National Medical Center
1500 East Duarte Road
Duarte, 91010
(800) 826-4673
genetherapy@coh.org
Children’s Hospital of Orange County
1201 W. La Veta Avenue
Orange, 92868
UCLA Health
757 Westwood Plaza
Los Angeles, 90095
310-260-6909
Children’s Hospital Los Angeles
4650 Sunset Boulevard
Los Angeles, 90027
(323) 361-4624
Covered CGT Access Model Services, suav nrog Fertility Preservation Services
What benefits and services can I receive under Medi-Cal’s CGT Access Model?
- Raws li CGT Access Model, cov nqi hauv qab no raug them:
- Ib qho ntawm ob cov tshuaj CGT rau SCD
- CASGEVY by Vertex Pharmaceuticals, Inc. – effective October 1, 2025.
- LYFGENIA by bluebird bio, Inc. – effective July 1, 2025.
- Ib qho ntawm ob cov tshuaj CGT rau SCD
- Fertility Preservation Services
- Raws li ib feem ntawm kev them nyiaj rov qab rau CGT SCD cov tshuaj, cov tuam txhab npog:
- Txog li peb ntu ntawm kev sau thiab khaws cia cov khoom tsim tawm (qe qe, sau cov phev, thiab / lossis cov nqaij mos extraction, thiab lwm yam). Cov txheej txheem tseeb thiab hom kev khaws cia fertility yuav raug txiav txim thiab pom zoo los ntawm Fertility Specialist kws kho mob thiab cov tswv cuab.
- Kev them nyiaj ua ntej txog li kaum tsib xyoos ntawm kev khaws cov qauv
- Ib qho kev sib tham thib ob hauv cov xwm txheej uas Tus Kws Kho Mob Fertility txiav txim siab tias tus tswv cuab tsis tsim nyog rau cov kev pabcuam khaws cia muaj menyuam
- Kev tsim nyog qhov chaw nyob, zaub mov, thiab cov nqi mus ncig kuj yuav raug them, yog tias tsim nyog tau txais cov kev pabcuam fertility preservation
- Raws li ib feem ntawm kev them nyiaj rov qab rau CGT SCD cov tshuaj, cov tuam txhab npog:
Dab tsi ntawm cov kev pabcuam fertility preservation tsis suav nrog hauv Tus Qauv?
Qee qhov piv txwv ntawm cov kev pabcuam uas TSIS suav nrog yog cov hauv qab no:
- Embryo (fertilized qe) creation
- Embryo (fertilized qe) cia
- In-vitro fertilization (tshwm sim sab nraum lub cev nrog kev pab cuam)
Kuv tuaj yeem txuas nrog cov peev txheej li cas?
Medi-Cal members who are considering or in the process of receiving bluebird bio’s LYFGENIA gene therapy treatment will receive Patient Navigators through my bluebird support, who can:
- Txuas cov tswv cuab nrog QTC, uas yog lub tsev kho mob tshwj xeeb uas tau kawm los tswj kev kho mob bluebird biogenes.
- Muab cov ntaub ntawv qhia txog ntau yam, suav nrog kev kho noob, kev xeeb tub, kab mob ntawm tes, thiab cov ntaub ntawv tshwj xeeb ntawm cov khoom.
- Pab cov tswv cuab nkag siab txog lawv qhov kev pov hwm kev pov hwm thiab cov nqi tawm hauv hnab tshos thiab tej zaum yuav muaj peev xwm txuas tau lawv nrog cov kev pab nyiaj txiag.
- Txhawb cov tswv cuab los ntawm txoj kev kho mob thiab txuas lawv mus rau cov peev txheej.
- Txiav txim siab tsim nyog rau thiab koom tes nrog cov kev pab cuam kho mob ntxiv, xws li kev pab mus ncig thiab chaw nyob
Please note that my bluebird support is available to members at no cost, and there is no obligation to move forward with CGT SCD treatment. To get connected with a Patient Navigator, please complete my bluebird support’s Program Enrollment Form.
Medi-Cal members who are starting treatment with Vertex Pharmaceuticals’ CASGEVY may enroll in Vertex Connects to receive a Case Manager, who can:
- Siv sijhawm los paub koj kom lawv tuaj yeem muab kev txhawb nqa muaj txiaj ntsig
- Teb cov lus nug txog kev kho mob thiab qhia cov lus qhia muaj txiaj ntsig los pab cov tswv cuab thiab lawv tsev neeg npaj rau txhua kauj ruam ntawm kev kho mob
- Coordinate lub logistics ntawm koj txoj kev kho mob
- Txiav txim siab tsim nyog rau thiab koom tes nrog cov kev pab cuam kho mob ntxiv, xws li kev pab mus ncig thiab chaw nyob
Enrollment in Vertex Connects Patient Support is not required to receive CASGEVY. However, a completed Vertex Connects enrollment form is needed to receive case management services and determine eligibility for certain program offerings. Members will receive a Vertex Connects enrollment form once they are prescribed CASGEVY treatment by their healthcare team.
What expenses are covered for the Medi-Cal member by the CGT therapy manufacturer if travel is necessary to receive fertility preservation services?
CGT therapy manufacturers are responsible for providing reimbursement to eligible members for mileage, tolls, and parking upon presentation of valid receipt, consistent with all applicable manufacturer policy. Manufacturers may also arrange transportation (via air, train, bus, car rental) for the member and caregivers to and from the fertility preservation provider. If an overnight stay is required, CGT therapy manufacturers may provide a modest single hotel room for up to two nights per visit and a reasonable per diem for food expenses for both the member and their parent/caregiver.
For more specific information about eligibility for travel coverage and reimbursement as well as for assistance with travel arrangements, members receiving bluebird bio’s LYFGENIA, should work with their assigned Patient Navigator and utilize my bluebird support. Similarly, members receiving Vertex’s CASGEVY should directly work with their Vertex Connects patient support team.
What benefits and services are NOT part of Medi-Cal’s CGT Access Model and how will I receive them?
Aside from the two CGT medications and, if needed, fertility preservation services, all other medical and non-medical services are not covered under the CGT Access Model and will be provided and covered depending on your Medi-Cal eligibility, as follows:
- Medi-Cal FFS:
- Cov kws kho mob FFS yuav tsum xa thiab xa daim nqi DHCS ncaj qha rau tag nrho lwm yam kev kho mob thiab tsis yog kev kho mob CGT cov kev pabcuam, suav nrog kev thauj mus los (sab nraum tus nqi ntawm cov tshuaj, kev tiv thaiv kev xeeb tub, thiab kev tsim nyog qhov chaw nyob, pluas noj, thiab kev mus ncig uas tsim nyog tau txais kev pabcuam fertility preservation raws li tau sau tseg saum toj no).
- Medi-Cal Managed Care:
- Tus tswv cuab ntawm Medi-Cal txoj kev npaj saib xyuas yuav tsum them rau tag nrho lwm yam kev kho mob thiab tsis yog kev kho mob CGT, suav nrog kev thauj mus los (sab nraum tus nqi ntawm cov tshuaj, kev txuag kev xeeb tub, thiab qhov chaw nyob tsim nyog, pluas noj, thiab kev mus ncig uas tsim nyog tau txais kev pabcuam fertility preservation, raws li tau hais saum toj no).
Tawm tswv yim
Where can I learn more about Medi-Cal’s CGT Access Model and/or provide feedback?
Information about Medi-Cal’s CGT Access Model is available on DHCS’ website, which is available at the following link: Feedback, questions, and comments may also be submitted to DHCS via email at dhcscgt@dhcs.ca.gov.